MEROPENEM – Aropen 1g

Aropen 1 g – Meropenem Trihydrate Powder for Injection/Infusion

• Active Ingredient:
Each vial contains meropenem trihydrate equivalent to 1 g anhydrous meropenem, stabilized with sodium carbonate.

• Form & Packaging:
White to pale-yellow sterile powder in a glass vial, supplied with one or two 10 mL sterile water ampoules for reconstitution .

• Indications:
Used to treat serious bacterial infections (both community-acquired and nosocomial) including:

• Pneumonia (including ventilator-associated)

• UTIs (complicated/uncomplicated)

• Intra-abdominal and gynaecological infections

• Skin and soft tissue infections

• Meningitis

• Septicemia and febrile neutropenia.

Dosage & Administration

• Adults (standard):

  • 500 mg IV every 8 h for less severe infections (e.g., skin, UTI, uncomplicated pneumonia)

  • 1 g IV every 8 h for severe infections (e.g., nosocomial pneumonia, peritonitis, sepsis)

  • Up to 2 g IV every 8 h for meningitis or cystic fibrosis-related infections.

• Pediatrics (≥3 months):

  • 10–40 mg/kg IV every 8 h, depending on severity and infection type .

• Renal impairment:

  • Dose adjustment based on creatinine clearance—reduced dose or frequency for CrCl <50 mL/min; supplemental dosing after hemodialysis .

• Administration:

  • Administer as a short IV bolus (~3–5 min) or infusion over 15–30 min after reconstitution with sterile water or compatible fluids.